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EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and …

2017-01-31 · Nonetheless, EBI2 was dispensable in active EAE. Human Th17 cells do also express EBI2, and EBI2 expressing cells are abundant within multiple sclerosis (MS) white matter lesions. These findings implicate EBI2 as a mediator of CNS autoimmunity and describe mechanistically its contribution to the migration of autoreactive T cells into inflamed ...

Pubmed.ncbi.nlm.nih.gov

The EBI2-oxysterol axis promotes the development of …

2019-02-11 · The gene encoding for Epstein-Barr virus-induced G-protein-coupled receptor 2 (EBI2) is a risk gene for inflammatory bowel disease …

Nature.com

The chemotactic receptor EBI2 regulates the homeostasis …

Here we found a difference in expression of the chemotactic receptor EBI2 (GPR183) on splenic DC subsets and that EBI2 regulated the positioning and homeostasis of DCs in the spleen. EBI2 and its main ligand, 7α,25-OHC, were required for the generation of the splenic CD4(+) DC subset and the localization of DCs in bridging channels. Absence of ...

Pubmed.ncbi.nlm.nih.gov

EBI2 augments Tfh cell fate by promoting interaction with …

2016-05-05 · EBI2 is expressed by CD4 T cells 11,12,13,14, but whether it has a role in positioning T cells during the early stages of activation has been unclear.Using an ovalbumin (OVA)-specific T-cell ...

Nature.com

Oxysterols direct immune cell migration via EBI2 | Nature

2011-07-27 · The EBI2 receptor (Epstein–Barr virus-induced gene 2, also known as GPR183) was recently shown to be linked to autoimmune disease, and is a critical regulator of the humoral immune response. It ...

Nature.com

Structures of oxysterol sensor EBI2/GPR183, a key …

2022-07-07 · Aberrant EBI2 signaling is implicated in inflammatory bowel disease, sclerosis, and infectious disease. Here, we report the cryo-EM structures of an EBI2-G i signaling complex with its endogenous agonist 7α,25-OHC and that of an inactive EBI2 bound to the inverse agonist GSK682753A. These structures reveal an agonist binding site for the ...

Pubmed.ncbi.nlm.nih.gov

GPR183 - Wikipedia

GPR183. G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein ( GPCR) expressed on the surface of some immune cells, namely B cells and T cells; in humans it is encoded by the GPR183 gene. [5] Expression of EBI2 is one critical mediator of immune cell localization within lymph ...

En.wikipedia.org

EMBL-EBI: EMBL's European Bioinformatics Institute

Overview of the European Bioinformatics Institute. EMBL-EBI. Unleashing the potential of big data in biology

Ebi.ac.uk

The EBI2 signalling pathway plays a role in cellular crosstalk …

2016-05-11 · EBI2 (Epstein-Barr virus-induced gene 2, GPR183) is a G protein-coupled receptor that is expressed in peripheral blood mononuclear cells 1,2,3 and activated by the oxysterol 7α25HC (7α, 25-dihydroxycholesterol) 4.EBI2 regulates B cell positioning in lymphoid tissue and is crucial for launching T cell-dependant antibody response 5,6.EBI2 is coupled exclusively to …

Ncbi.nlm.nih.gov

EBI2 | definition of EBI2 by Medical dictionary

GPR183: A gene on chromosome 13q32.3 that encodes a G protein-coupled receptor closely related to the thrombin receptor. GPR183 expression is detected in B cells, but not in T cells; its function is unknown.

Medical-dictionary.thefreedictionary.com

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