Calpain.net

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Calpain - Wikipedia

A calpain is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain proteases, the small regulatory subunit CAPNS1, also kno…

En.wikipedia.org

Calpain signaling: from biology to therapeutic opportunities in ...

Web Sep 5, 2023 · Calpain signaling, with its diverse roles in cellular processes, has attracted attention as a potential therapeutic target in these neurodegenerative diseases. This …

Ncbi.nlm.nih.gov

The Critical Role of Calpain in Cell Proliferation - PMC

Web Aug 21, 2021 · Calpain are implicated in many physiological and pathological processes. They have significant role in the cell proliferation, differentiation and migration in a variety …

Ncbi.nlm.nih.gov

Calpain-2 as a therapeutic target for acute neuronal injury

Web Jan 18, 2021 · Expert opinion. As evidence accumulates that calpain-2 activation participates in acute neuronal injury, there is interest in developing therapeutic …

Ncbi.nlm.nih.gov

The calpains: modular designs and functional diversity

Web Aug 6, 2007 · In mammals and plants it is clear that a calpain plays an essential role in development. There is increasing evidence that ubiquitous calpains participate in a variety of signal transduction pathways and …

Genomebiology.biomedcentral.com

Calpain-1 and Calpain-2 in the Brain: New Evidence for a

Web Dec 16, 2020 · Calpains are a family of soluble calcium-dependent proteases that are involved in multiple regulatory pathways. Our laboratory has focused on the …

Pubmed.ncbi.nlm.nih.gov

The calcium-dependent protease calpain in neuronal remodeling …

Web calcium homeostasis. ischemia. dendritic pruning. Calpains are cysteine proteases activated by Ca2+. Calpain was first discovered in 1964 during studies of proteolytic processes …

Cell.com

How calpain is activated by calcium - Nature

Web Apr 1, 2002 · Calpains are a family of cytosolic cysteine proteinases whose enzymatic activities depend on Ca 2+. Members of the calpain family are believed to function in …

Nature.com

Effects of functionally diverse calpain system on immune cells

Web Jan 23, 2021 · Calpains are a family of nonlysosomal cysteine proteases, which play important roles in numerous physiological and pathological processes. Locations of them …

Link.springer.com

The calpain system - PubMed

Web Calpain. The calpain system originally comprised three molecules: two Ca2+-dependent proteases, mu-calpain and m-calpain, and a third polypeptide, calpastatin, whose only …

Pubmed.ncbi.nlm.nih.gov

The calcium-dependent protease calpain in neuronal remodeling …

Web Neurosciences. Review. The calcium-dependent protease calpain in neuronal remodeling and neurodegeneration. Elsayed Metwally,1,2,3 Guoli Zhao,1,4 and Yong Q. Zhang1,2,* …

Cell.com

Calpine | America’s Premier Power Generation Company

Web Calpine is America’s largest generator of electricity from natural gas and geothermal resources and one of the largest retail providers of power.

Calpine.com

Nylander, Lindholm exchange goals to open scoring in Game 7

Web 2 hours ago · Watch as Maple Leafs’ William Nylander opens the scoring in the third period, but loses the lead quickly with a game-tying goal by fellow Swede Hampus Lindholm.

Sportsnet.ca

Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical …

Web Dec 16, 2020 · Calpains are a family of soluble calcium-dependent proteases that are involved in multiple regulatory pathways. Our laboratory has focused on the …

Ncbi.nlm.nih.gov

'Again...': Maple Leafs fans in shambles after another …

Web 1 hour ago · Maple Leafs fans in shambles after another heartbreaking end to season. Fans watch the Toronto Maple Leafs play the Boston Bruins in game 6 of first-round NHL …

Sportsnet.ca

Calpains: an elaborate proteolytic system - PubMed

Web Calpain is an intracellular Ca (2+)-dependent cysteine protease (EC 3.4.22.17; Clan CA, family C02). Recent expansion of sequence data across the species definitively shows …

Pubmed.ncbi.nlm.nih.gov

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